Erastapex Trio 40/10/25 Mg

Erastapex Trio 40/10/25 mg

Description:

Erastapex Trio 40/10/25 mg is a prescription antihypertensive medicine combining three active ingredients: olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide. It is formulated as film-coated tablets for the treatment of high blood pressure (hypertension) in adults who require combination therapy to achieve adequate blood pressure control. By targeting different mechanisms that regulate blood pressure, Erastapex Trio helps reduce cardiovascular risk and supports long-term heart and vascular health under medical supervision.

Indications:

• Treatment of essential hypertension (high blood pressure) in adults.
• Patients whose blood pressure is not adequately controlled by dual therapy with any two of the following: an angiotensin ii receptor blocker (such as olmesartan), a calcium channel blocker (such as amlodipine), or a thiazide diuretic (such as hydrochlorothiazide).
• Management of patients who require a fixed-dose triple combination to simplify dosing and improve adherence to antihypertensive therapy.
• Helps reduce the risk associated with uncontrolled high blood pressure, such as stroke, heart attack, and kidney damage, when used as part of a comprehensive cardiovascular risk management plan as directed by a physician.

Active Ingredients / Key Components:

• Olmesartan medoxomil – 40 mg per film-coated tablet (angiotensin ii receptor blocker, arb).
• Amlodipine (as amlodipine besylate) – 10 mg per film-coated tablet (dihydropyridine calcium channel blocker).
• Hydrochlorothiazide – 25 mg per film-coated tablet (thiazide diuretic).
• Other excipients: film-coating and tablet core excipients (full list of inactive ingredients is not available in the provided information; refer to the official package insert for complete details).

Dosage & Administration / How to Use:

• Erastapex Trio 40/10/25 mg is for oral use only and should be taken exactly as prescribed by your physician.
• Usual dose: one film-coated tablet once daily, preferably at the same time each day.
• Can be taken with or without food; swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
• Dose selection and any adjustment should be made by the treating physician, usually after titration with the individual components (olmesartan, amlodipine, hydrochlorothiazide) or their dual combinations.
• Do not stop taking Erastapex Trio without consulting your doctor, even if you feel well, as high blood pressure often has no symptoms.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
• Use with caution in elderly patients or those with kidney or liver impairment; dosing and monitoring must be determined by a healthcare professional.

Clinical Benefits:

• Provides powerful blood pressure reduction by combining three complementary mechanisms: blockade of angiotensin ii receptors (olmesartan), vasodilation via calcium channel blockade (amlodipine), and increased sodium and water excretion (hydrochlorothiazide).
• Helps maintain more consistent 24-hour blood pressure control, which may reduce the risk of cardiovascular events when used as part of long-term hypertension management.
• Simplifies treatment in patients who require triple therapy by offering three active ingredients in a single daily tablet, supporting better adherence.
• Reduces peripheral vascular resistance and fluid overload, helping to lower strain on the heart and protect vital organs such as the brain, heart, and kidneys over time.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to olmesartan, amlodipine, hydrochlorothiazide, other sulfonamide-derived drugs, or any of the excipients.
• Contraindicated during pregnancy, especially in the second and third trimesters, due to risk of injury and death to the developing fetus. If pregnancy is detected, stop Erastapex Trio immediately and contact your doctor.
• Contraindicated in severe renal impairment, anuria, or severe hepatic impairment, and in patients with refractory hypokalemia, hypercalcemia, or symptomatic hyperuricemia/gout related to thiazide use (as determined by a physician).
• Use with caution in patients with kidney disease, liver disease, heart failure, aortic stenosis, hypertrophic cardiomyopathy, electrolyte imbalance (low potassium, sodium, or magnesium; high calcium), diabetes, gout, or systemic lupus erythematosus.
• May cause symptomatic hypotension, especially in volume- or salt-depleted patients (e.g., on high-dose diuretics, low-salt diet, diarrhea, or vomiting). Initiation and dose changes should be supervised by a doctor.
• Hydrochlorothiazide may increase blood sugar, uric acid, and lipids; monitoring is recommended in diabetic or gout patients.
• Amlodipine may cause peripheral edema and should be used cautiously in patients with heart failure or significant valvular disease.
• Olmesartan and hydrochlorothiazide can affect kidney function; periodic monitoring of renal function and electrolytes (potassium, sodium, creatinine) is recommended.
• Consult your doctor before use if pregnant, planning pregnancy, nursing, taking other medications (especially other antihypertensives, diuretics, lithium, nsaids, potassium supplements, or drugs affecting potassium), or if you have any chronic medical conditions.
• May cause dizziness or fatigue; use caution when driving or operating machinery until you know how the medicine affects you.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision; it is a prescription-only antihypertensive medicine.
• Keep out of reach of children.

Side Effects:

• Common side effects may include dizziness, headache, fatigue, flushing, palpitations, ankle or leg swelling (peripheral edema), nausea, abdominal discomfort, and increased urination.
• Possible laboratory changes include low potassium (hypokalemia), low sodium (hyponatremia), increased uric acid, increased blood sugar, and changes in kidney function tests; your doctor may order periodic blood tests.
• Less common but serious side effects can include severe hypotension, allergic reactions (rash, itching, swelling of the face, lips, tongue, or throat), difficulty breathing, chest pain, irregular heartbeat, severe abdominal pain, or signs of kidney problems (reduced urine output, swelling, unusual fatigue).
• Very rare cases of severe skin reactions, worsening of lupus, or cholestatic jaundice have been reported with related components; seek immediate medical attention if you notice yellowing of the skin or eyes, dark urine, or severe skin rash.
• Stop the medicine and seek urgent medical help if you experience signs of angioedema (swelling of face, lips, tongue, or throat) or severe allergic reaction.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children. Do not use after the expiry date printed on the pack. Store at or below the temperature recommended on the package insert (specific temperature range not available in the provided information; refer to the official packaging).

Specifications:

• Product type: prescription antihypertensive medicine.
• Form: film-coated tablet.
• Strength per tablet: olmesartan medoxomil 40 mg + amlodipine 10 mg + hydrochlorothiazide 25 mg.
• Pack size: 30 film-coated tablets (30 f.c. tabs) per pack.
• Route of administration: oral.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.